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Category 1† Recommendation for encorafenib in combination with binimetinib as a first-line systemic therapy option for patients with metastatic or unresectable cutaneous melanoma with a BRAF V600–activating mutation included in NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Cutaneous Melanoma, Version 1.2022.5
14.9 MONTHS (n=192; 95% CI: 11.0-18.5)
BRAFTOVI + MEKTOVI
7.3 MONTHS (n=191; 95% CI: 5.6-8.2)
Primary Analysis: (HR=0.54 [95% Cl: 0.41-0.71], P<0.0001)
In the metastatic setting, 5% of patients receiving BRAFTOVI + MEKTOVI in the COLUMBUStrial had prior treatment with immunotherapy.4
NCCN Guidelines® include encorafenib (BRAFTOVI) in combination with binimetinib (MEKTOVI) as one of the Category 1† options, among other recommended regimens, for patients with metastatic or unresectable melanoma who harbor a BRAF V600-activating mutation5
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Melanoma: Cutaneous V.2.2023.5
Over 8,500 adult patients with unresectable or metastatic melanoma with a BRAF V600E/K mutation have been prescribed BRAFTOVI + MEKTOVI since FDA approval4‡
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BRAFTOVI® (encorafenib) and MEKTOVI® (binimetinib) are kinase inhibitors indicated for use in combination for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved test.
Limitations of Use: BRAFTOVI is not indicated for treatment of patients with wild-type BRAF melanoma.